| Coronavirus frameshifting stimulation element | |
|---|---|
| Predicted secondary structure and sequence conservation of Corona_FSE | |
| Identifiers | |
| Symbol | Corona_FSE |
| Rfam | RF00507 |
| Other data | |
| RNA type | Cis-reg; frameshift_element |
| Domain(s) | Viruses |
| SO | 0000233 |
In molecular biology, the coronavirus frameshifting stimulation element is a conserved stem-loop of RNA found in coronaviruses that can promote ribosomal frameshifting. Such RNA molecules interact with a downstream region to form a pseudoknot structure; the region varies according to the virus but pseudoknot formation is known to stimulate frameshifting. In the classical situation, a sequence 32 nucleotides downstream of the stem is complementary to part of the loop. In other coronaviruses, however, another stem-loop structure around 150 nucleotides downstream can interact with members of this family to form kissing stem loops and stimulate frameshifting.[1]
Other RNA families identified in the coronavirus include the SL-III cis-acting replication element (CRE), the coronavirus 3' stem-loop II-like motif (s2m), the coronavirus packaging signal and the coronavirus 3' UTR pseudoknot.